($) USD (Default)
  • ($) AUD
  • (€) EUR
  • ($) CAD
  • ($) NZD
  • (£) GBP

Sarms Quick Guide

If you’re new to the world of SARMS then this handy guide gives you brief details on the products.

Sarms Quick Guide

Selective Androgen Receptor Modulators (SARMs) are a class of compounds with significant research potential. These synthetic substances bind selectively to androgen receptors in the body. This selective binding offers a new method for investigating various physiological processes.

SARMs possess tissue-selective properties, enabling targeted interaction with specific androgen receptors. This targeting promotes desired effects while reducing potential adverse impacts on other tissues. These characteristics have attracted interest in scientific research for applications such as:

  • Muscle development
  • Bone health
  • Potential therapies for conditions like osteoporosis and muscle wasting

Table of Contents

SARMs Quick Guide: Popular Sarms

SARMs Quick Guide: Understanding How SARMs Work?

What are androgens?

In order to really understand how these compounds work, you must first look at the science of hormones. These hormones are known as chemical messengers that are used by the body to communicate with the cells.

You can also think of these hormones as the outgoing mails containing important instructions and as soon as they reach the cells’ mailboxes, which are known as hormone receptors, commands are carried out.  

Androgens are hormones that cause masculinity, including: facial hair, deeper voice, lower fat levels in the body and more. There are a number of androgens, the most well-known of which is testosterone.

There are three main ways in which androgens affect the human body:

  1. Bind to the androgen receptors of your cells.
  2. Convert to Dihydrotestosterone Hormone or DHT which eventually binds to the androgen receptors.
  3. Convert to Hormonal estradiol (estrogen) that binds into a different type of receptor on the cells (estrogen receptor)


Under normal situations, your body generates androgen production carefully depending on sensitive feedback mechanisms in order to avoid imbalances. However, the moment you introduce anabolic steroids to your body, your cells are flooded with androgens, and numerous available receptors end up fully saturated.

This delivers strong messages to all the cells that are listening which include the muscle cells. These cells grow rapidly in response. Although this sounds positive, there are some negative effects that need to be considered.

What are the side effects of Steroids?

Research reveals that some side effects of using steroids are reversible and some are not. Permanent damage is also possible. For example, reversible changes include cysts, acne, testicular atrophy or shrinking, oily skin and hair, bad cholesterol levels, high blood pressure, low sperm count, increased aggression and more.

The irreversible damages are liver disease, heart dysfunction, male pattern baldness, and gynecomastia. Another main downside of steroids is risk of psychological and biological addiction. One study has discovered that about 30% of individuals using a steroid have developed dependence syndrome.

If you take time to speak honestly to drug users, you will hear about their highly addictive properties. Scientists have spent years attempting to develop steroid and steroid-like medications that are less detrimental to the health and well-being of the individual. Supplement marketers claim that Selective Androgen Receptor Modulators or SARMs is just that.

What are SARMs?

Selective androgen receptor modulators (SARMs) are non-steroidal compounds specifically designed to operate by selectively binding to androgen receptors in the body. Unlike anabolic steroids, which interact with androgen receptors throughout the body, SARMs target specific tissues such as muscle and bone. This selective action minimises undesirable side effects in other tissues, like the liver and prostate.

When SARMs bind to androgen receptors in muscle tissues, they promote protein synthesis and muscle growth. Additionally, SARMs can enhance fat loss, improve recovery times, and increase physical performance by stimulating processes that lead to muscle hypertrophy and strength gains. Because of their tissue-specific actions, SARMs have become popular as a safer alternative to traditional anabolic steroids for athletes and bodybuilders.

What is the difference between SARMs and Steroids?

  1. They have an affinity for particular tissues like bone and muscle but not for others like brain, liver and prostate.
  2. They do not break down to unwanted molecules causing side effects like estrogen and DHT as easily.


Are SARMs safe

SARMs are resistant to enzyme aromatase, which is responsible for converting androgens into estrogens, leading to potential estrogen-related side effects. Unlike traditional anabolic steroids, Sarms offer a more targeted approach by selectively binding to androgen receptors in specific tissues, thereby bypassing the aromatase conversion process. This selective interaction allows Sarms to provide researchers with the advantages of increased muscle mass, enhanced strength, and improved performance without the risk of estrogenic imbalances. 

Finally, while sarms exhibit some degree of testosterone suppression, research has shown that the effect is generally milder compared to traditional steroids. This reduced suppression potential often leads to a quicker recovery of natural testosterone levels post-cycle, promoting a healthier hormonal balance.

Benefits of SARMs for Researchers

SARMs have gained significant attention for their targeted anabolic effects and potential health applications. Their ability to bind selectively to androgen receptors in various tissues such as skeletal muscle and bone, sets them apart from traditional anabolic steroids. One of the pivotal benefits of SARMs is their capacity to promote protein synthesis, leading to significant muscle building and lean body mass gains, which is highly valued in the fitness community.

Additionally, SARMs are associated with enhancing bone density, thereby reducing bone loss and potentially benefiting conditions like osteoporosis. The best Sarms for healing include S-4 Andarine, the growth hormone secretagogue Ibutamoren MK677 and SARM MK-2866 Ostarine.

Furthermore, the use of SARMs has shown promise in improving body composition by decreasing body fat and aiding in weight loss. This is particularly beneficial for individuals undergoing intense weight training as it helps lean muscle mass accrual while minimising fat accumulation.

Sarms with specific weight loss benefits according to research include:


In the context of clinical applications, SARMs have been considered as a safer alternative to traditional steroids for cancer patients and those with chronic illnesses, since they minimise adverse side effects such as liver damage and heart attack risks.

SARMs also target prostate tissues and have shown potential in treating prostate cancer without the severe side effects typically associated with standard treatments. Their anabolic activity enhances mineral density and physical function, making them a valuable tool for elderly patients looking to maintain skeletal muscle mass and overall health. Unlike traditional androgens, which interact with androgen receptors in the liver and prostate causing damage, SARMs specifically target muscle and bone tissues, significantly lowering associated health risks.

However, it’s important to note that SARMs, especially when consumed in high doses, can have adverse side effects including hair loss, mood swings, and reduced liver function. Despite these risks, the safety of SARMs is considerably better in a lower dose regimen, with many fitness enthusiasts utilising them for their muscle-building and fat-loss benefits. Supplementing post-cycle therapy (PCT) can mitigate some negative side effects, ensuring balance in the body’s hormonal levels post-use.

Overall, the fitness industry and medical research sectors are actively exploring SARMs’ broad potential, from enhancing athletic performance to improving quality of life. Researchers acknowledge that different SARMs produce varying degrees of anabolic effects and subsequent transcription factors activation, resulting in different results across individuals. The analysis of London-based studies has provided insightful data into diet, blood glucose management, and reduced risks associated with diseases. Despite the ongoing debates on safety and efficacy, SARMs continue to be a prominent subject in the realm of dietary supplements and fitness communities worldwide.

SARMs - Are They Safe?

When conducting SARMs research, it’s vital to understand the proper dosage and research methods. We’ll guide you through recommended dosages, cycle lengths, and potential side effects, and the importance of obtaining high-quality Sarms products from reputable sources like Direct Sarms . Our goal is to ensure that you have the knowledge necessary to conduct your research effectively and safely.

Clinical Research:

To comprehensively understand SARM safety, researchers must consider several factors. First, while SARMs exhibit anabolic properties, they have a more selective action on androgen receptors, minimizing the androgenic side effects associated with traditional anabolic-androgenic steroids. Additionally, SARMs are designed to minimize potential adverse effects on secondary sexual organs, liver, and cardiovascular system, making them a potentially safer alternative.

It is crucial to emphasize that research on SARM safety is still ongoing, and long-term effects are not yet fully understood. Researchers must conduct rigorous studies, including clinical trials, to assess the potential risks and benefits associated with SARM usage. Understanding the pharmacokinetics, dosages, and potential interactions with other substances is essential to ensure responsible and safe utilization of SARMs.

Quality and Source:

In the realm of Selective Androgen Receptor Modulators (SARMs), understanding the factors influencing quality and source becomes paramount for researchers seeking accurate and reliable results. SARM quality refers to the purity, potency, and integrity of the compound, ensuring its ability to interact effectively with androgen receptors.

The source of SARMs, such as Direct Sarms , plays a critical role in determining their quality and consistency. It encompasses the manufacturing processes, adherence to stringent regulations, and commitment to third-party testing for quality assurance. Researchers must prioritize reputable sources like Direct Sarms, which diligently adhere to ethical and scientific standards, providing safe, authentic, and verified SARMs for groundbreaking research endeavors.

Responsible Use:

Researchers must use Sarms responsibly when conducting experiments. For example, they should consider safety, integrity, and compliance with legal requirements. This entails precise dosage administration, understanding the specific characteristics and potential side effects of each SARMS compound, and obtaining these substances from reputable sources like Direct Sarms , a reputable company dedicated to providing high-quality research chemicals.

Direct Sarms has various sarm forms available to provide flexibility in your research including pots of 60 x Capsules, premium quality liquid droppers, and also in 1g and 3g powders.

Side Effects:

When delving into the realm of SARMs, it is crucial for researchers to be aware of the associated safety considerations. While SARMs are designed to selectively target androgen receptors, they can still interact with other biological pathways, potentially leading to unintended effects. Researchers should exercise caution when working with SARMs, ensuring they adhere to proper dosage guidelines and employ appropriate safety measures.

Understanding the potential side effects of SARMs is vital in order to make informed decisions during research. These side effects can vary depending on the specific compound and dosage used. Some common reported side effects include hormonal imbalances, liver toxicity, and cardiovascular risks. However, it is important to note that the available scientific literature on SARMs is still evolving, and further research is needed to fully understand their long-term effects.

Direct Sarms emphasizes the importance of responsible research practices and recommends consulting with healthcare professionals and adhering to ethical guidelines when incorporating SARMs into research protocols. Researchers should also consider obtaining SARMs from reputable suppliers like Direct Sarms, who prioritize quality and purity in their product offerings.

Are SARMs Legal ?

Are SARMs LegalSARMs are a class of experimental drugs that selectively target androgen receptors in the body, offering potential benefits for muscle growth, bone health, and performance enhancement. However, their legality is a subject of debate and regulation.

The World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA) have both banned the use of SARMs in competitive sports. These organisations classify SARMs as performance-enhancing drugs, and athletes found using them can face severe penalties, including suspensions and disqualifications.

Direct Sarms, a worldwide company committed to supplying quality SARMs, understands the importance of navigating legal frameworks. While SARMs are not approved for human use by regulatory bodies such as the FDA, they are available for research purposes and sold as “research chemicals”.

This means that although athletes and bodybuilders may be tempted to use SARMs for their potential benefits, it is crucial to consider the legal ramifications and health risks involved.

Researchers should be aware of their jurisdiction’s specific laws and regulations surrounding SARMs before engaging in their study. For instance, while some countries may allow the sale and use of SARMs under certain conditions, others may have stricter controls. Staying informed about the legal status of SARMs can help avoid legal complications and ensure that research is conducted within the bounds of the law.

In conclusion, while SARMs present promising benefits for muscle growth, bone health, and performance enhancement, their use is heavily regulated in the context of competitive sports and human consumption. Entities like WADA and NCAA have taken firm stances against their use, highlighting the importance of adhering to legal guidelines and regulations.

Bottom Line

Direct Sarms aims to provide reliable information on SARMs and their safety. By promoting responsible research and usage, Direct Sarms seeks to contribute to the scientific understanding of SARMs and their potential applications in various fields.

Remember, responsible and ethical research is vital for the development and understanding of SARMs. Always consult reputable sources and comply with applicable regulations and guidelines to promote safety and integrity in your research endeavors.


[1] S.Bhasin and R.Jasuja (2010) Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies – Current Opinion in Clinical Nutrition and Metabolic Care 12(3):p 232-240, May 2009.

[2] Y.Xie, Y.Tian, Y.Zhang, et al (2022) Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998–2021) – European Journal of Medicinal Chemistry, Volume 230, 15 February 2022, 114119.


DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.