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Does Testolone RAD-140 Increase Testosterone?

RAD-140 testolone
Table of Contents

Does Testolone RAD-140 Increase Testosterone?

When it comes to Selective Androgen Receptor Modulators (SARMs) in research, RAD-140 Testolone stands out. It is a high-affinity androgen receptor modulator known for its potent anabolic effects on muscle growth and lean body mass. Researchers have explored its potential use in conditions like breast cancer and prostate cancer, but one key question remains: Does RAD-140 increase testosterone levels?

This article will break down the science behind RAD-140, focusing on its role in research. Remember, RAD-140 and all SARMs are strictly for research purposes and not for human use.

Does RAD-140 Increase Testosterone?

RAD-140 Testolone is a Selective Androgen Receptor Modulator (SARM), meaning it binds to androgen receptors (AR) in muscle and bone. This leads to anabolic effects, similar to anabolic androgenic steroids, but with fewer adverse effects related to estrogen receptors (ER) or the prostate.

However, instead of boosting natural testosterone synthesis, RAD-140 suppresses testosterone levels. This occurs because the body recognizes the compound and slows down its own testosterone production. Studies on immature male rats have shown that RAD-140 can impact the levator ani muscle and seminal vesicles, suggesting testosterone suppression.

RAD-140 Testolone

Can RAD-140 Be Used in Testosterone Replacement Therapy (TRT)?

In clinical trials, anabolic androgenic steroids like Testosterone and DHT (Dihydrotestosterone) have been studied for testosterone replacement therapy (TRT). Since RAD-140 mimics some effects of testosterone, some researchers speculate whether it could be useful for TRT.

However, TRT requires a hormone that supports testosterone synthesis, libido, mood, and overall health. RAD-140 Testolone does not fully replicate natural testosterone’s broad functions. Additionally, its suppression of testosterone levels makes it unsuitable as a standalone TRT option. More systematic reviews and clinical trials are needed to assess its full efficacy.

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Does RAD-140 Require Post-Cycle Therapy (PCT)?

Since RAD-140 suppresses testosterone synthesis, researchers explore Post-Cycle Therapy (PCT) methods after its use. In research settings, compounds like Clomiphene Citrate or Tamoxifen Citrate are studied for their ability to restore hormonal balance.

PCT works by stimulating Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which encourage the body to restart natural testosterone synthesis. Some research also looks at Human Chorionic Gonadotropin (HCG) as a way to boost testosterone levels post-study.

Is RAD-140 Safe?

The use of SARMs like RAD-140 Testolone is still under investigation. While it is highly selective for androgen receptors, reducing prostate-related risks, its long-term effects remain unknown. Some clinical trials suggest that it has fewer adverse effects than steroids, but there are concerns about liver injury and liver failure.

The FDA has not approved RAD-140 Testolone for medical use, meaning it is not available through a healthcare provider. Drug administration of SARMs is strictly for research, and using them outside of controlled studies may lead to inconvenience due to regulatory restrictions.

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RAD-140 in Cancer Research

Some studies are exploring SARMs like RAD-140 for treating metastatic breast cancer and prostate cancer. Since it selectively binds to androgen receptors, it may help prevent estrogen receptor (ER)-driven cancers. Scientists have contributed to systematic reviews on SARMs’ potential roles in cancer therapy. However, much more research is required before any conclusions can be drawn.

Can HCG Be Used to Increase Testosterone Levels?

Human Chorionic Gonadotropin (HCG) is often studied for its role in testosterone production. It works by acting like luteinizing hormone (LH). LH tells the testes to make more testosterone.

In research with compounds like RAD-140, scientists may look at HCG for post-cycle recovery. Some studies suggest that HCG could help bring back natural testosterone production faster by stimulating testicular function.

But this is still being studied. Like other hormonal compounds, using HCG requires precise dosing and close monitoring. Without it, there is a risk of messing up the body’s endocrine function. Explore HCG peptides from  Direct Sarms

Moving Forward with RAD-140 Research

RAD-140 Testolone is an exciting compound in SARM research, known for its potent anabolic effects and high affinity for androgen receptors. However, its testosterone suppression, potential adverse effects, and lack of FDA approval mean that further studies are essential.

If you are conducting research on RAD-140 Testolone, ensure that studies comply with ethical guidelines and are conducted through official government organizations, gov websites, or regulated institutions. Sensitive information regarding SARM studies should always be handled with care.

While this compound promise, systematic review and clinical trials will determine its true efficacy in muscle preservation, hormone therapy, and disease treatment. As always, SARMs like RAD-140 are strictly for research purposes—not for human use.

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When seeking RAD-140 Testolone for your research or other SARMs, it is crucial to source them from a reputable supplier like Direct SARMs. We offer a wide range of high-quality research products, ensuring customer satisfaction and safety.

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References:

[1] Z.J.Solomon, J.Rivera Mirabal, D.J.Mazur, et al (2019) Selective Androgen Receptor Modulators (SARMs) – Current Knowledge and Clinical Applications – Sexual Medicine Reviews, Volume 7, Issue 1, January 2019, Pages 84-94.

[2] A.Jayaraman, A.Christensen, V.A.Moser, et al (2014) Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats – Endocrinology, 2014 Apr; 155(4): 1398–1406.

[3] Leung K, Yaramada P, Goyal P, Cai CX, Thung I, Hammami MB. RAD-140 Drug-Induced Liver Injury. Ochsner J. 2022 Winter;22(4):361-365.

[4] Brown AM, Ganjayi MS, Baumann CW. RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice. Clin Exp Pharmacol Physiol. 2023 Dec;50(12):973-983.


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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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